Barbara
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My loved one has been using this product almost 3 weeks now and I have begun to notice positive cognitive improvement. Their mood overall has been more positive.
 (18552 Reviews)

Cerefolin Brain Wellness Targeted Nutrition Neurologist Recommended 30 Count

Cerefolin Brain Wellness Targeted Nutrition Neurologist Recommended 30 Count

$65.99
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  • Supports Memory and Cognitive Function: Improves concentration, memory and focus.
  • Brain Supporting Ingredients: L-Methylfolate Calcium, Vitamin B12 (Methylcobalamin), and NAC (N-Acetyl-l-cysteine) work together to support neurotransmitter function, brain metabolism.
  • Daily Cognitive Support for Memory and Focus: Designed for those looking to help maintain cognitive performance over time, available in 30 day supply.
  • Targeted Nutrition for Cognitive Support: Cerefolin provides specialized nutrition to help support healthy brain function and cognitive wellness when diet alone may not be enough.

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Directions

Use under medical supervision. †† Take one caplet daily either with or without food. Do not exceed the recommended dosage.

Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have any medical condition.

Cerefolin Brain Wellness™ targeted nutrition is best when used long-term. Some users begin seeing results after 45 days of use, but results and timing of results vary.*

Ingredients

Dietary Ingredients

  • 6 mg L-Methylfolate Calcium – This active form of folate supports memory- and focus-related neurotransmitter production, while improving brain metabolism.
  • 2 mg Vitamin B12 (Methylcobalamin) – This vitamin boosts energy production to support overall brain function.
  • 600 mg N-Acetyl-l-cysteine (NAC) – This antioxidant contributes to brain health by reducing oxidative stress.

Together these ingredients efficiently decrease homocysteine levels, which can help limit blood vessel damage and brain shrinkage linked to cognitive decline.

Ingredients

N-Acetyl-l-cysteine (NAC), Microcrystalline Cellulose and Silicon Dioxide, Hypromellose, L-Methylfolate Calcium, Magnesium Stearate (NF, Vegetable Source), Methylcobalamin.

Contraindications

Cerefolin Brain Wellness™ is contraindicated in patients with known hypersensitivity to any of the components contained in this product.

Warnings & Storage

Keep out of reach of children.

Store in a cool, dry place at a controlled room temperature of 59°F to 86°F (15°C to 30°C). Protect from heat, light, and moisture.

Brain Results You Can't Ignore

11.2x Slower Brain Shrinkage

A clinical study showed patients taking Cerefolin Brain Wellness™ had an 11.2 times slower rate of brain shrinkage than those not taking it.1*

Better Cognitive Outcomes Over Time

An MRI study showed long-term use (over 2+ years) was associated with significantly better cognitive outcomes.1*

Continued Use After 90 Days

After using the product for 90 days, 94% of users said once they tried it, they planned to continue.4*

    Cerefolin Brain Wellness™ Is

    • Major Allergen Free*

    • Caffeine Free

    • Dye Free

    • Gluten Free

    • Non-GMO

    • Preservative Free

    • Sodium Free

    • Sugar Free

    • Titanium Dioxide Free

    • Vegan

      Targeted Nutrition Helps Lower Elevated Homocysteine Levels

      L-methylfolate, methylcobalamin, and N-acetyl-l-cysteine efficiently decrease homocysteine levels, mitigating vascular damage and brain atrophy linked to cognitive decline. Compared to those with no HHcy and not taking Cerefolin Brain Wellness™:1-3*

      • Hippocampal atrophy slowed by 4.25 times1*
      • Cortical atrophy slowed by 11.2 times 1*

      The relationship between plasma homocysteine and cognitive decline warrants preventive strategies to preserve cognitive function17,18

      Homocysteine Elevating Factors

      • Demographics 19-23

        ● Increased Age

        ● Male

        ● Menopause

        ● Race

      • Vitamin Deficiencies20

        ● Folate

        ● B12

      • Diseases20,24,25

        ● Chronic renal failure

        ● Diabetes

        ● Hypothyroidism

      • Drugs16,26-30

        ● Anticonvulsants

        ● Levodopa

        ● Metformin

        ● Methotrexate

        ● Nitrous oxide

        ● Oral contraceptives

        ● Proton pump inhibitors

      • Lifestyle24,31,32

        ● Alcohol abuse

        ● Methionine-rich animal protein diet

        ● Physical inactivity

        ● Tobacco smoking

      • Genetic Alterations

        ● Methylenetetrahydrofolate
        reductase (MTHFR)

        The Predictive Value of Homocysteine

        In the Framingham Study of homocysteine and cognitive performance, they found:

        • A statistically significant inverse association between elevated homocysteine (Hcy) and cognitive performance in individuals 60 years of age or older.8
        • Early intervention may be important because the inverse association between Hcy and cognitive performance was observed beyond middle age.8

        Proven to Slow the Change in Predicted Memory Performance

        Starting Cerefolin Brain Wellness™* early can help delay cognitive decline in tasks of memory and constructional praxis. Longer-term treatment may be associated with significantly slower decline compared to those not on therapy. Improvements were seen in sequencing, response inhibition, and constructional praxis in a follow-up study.2,3*

        Dual Action Formula

        Targeted nutrition for Mild Cognitive Impairment (MCI).

        Improves

        Brain Health

        Cerefolin Brain Wellness™ helps support overall brain function by providing essential nutrients that aid in reducing harmful homocysteine levels, which can negatively impact brain health.3*

        Memory & Focus

        Individuals taking Cerefolin Brain Wellness™ showed improvement in memory and ability to focus on daily activities.4*

        Concentration

        Cerefolin Brain Wellness™ helped people maintain attention and stay on task, which are essential for completing daily tasks and decision-making processes.4*

        Slows

        Cognitive Decline

        Long-term use of Cerefolin Brain Wellness™ was associated with a significantly slower rate of cognitive decline, especially in individuals with mild cognitive impairment.2*

        Brain Atrophy

        Research shows that people with mild cognitive impairment (MCI) and elevated homocysteine who took Cerefolin Brain Wellness™ experienced slower brain shrinkage — helping support memory, thinking skills, and overall brain health.1*

        Trust in the Results

        Neurologists recommend Cerefolin Brain Wellness™*. Starting early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.1-3

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        Clinically Proven To

        Slow the rate of brain shrinkage by 11.2x1*

        Strong Loyalty

        94% who used product for 90 days said they planned to continue4*

        Free From

        Gluten, dyes, sugar, sodium, caffeine, preservatives, GMOs, titanium dioxide and major food allergens*

        Why Cerefolin Brain Wellness™?

        More than just memory support, dual-action Cerefolin Brain Wellness™ slows cognitive decline and brain shrinkage while also improving brain health, memory, focus and concentration.1-4

        Help Protect Your Brain with Targeted Nutrition

        This product is neurologist-recommended* targeted nutrition your body cannot get from diet alone. Previously sold by prescription-only, Cerefolin Brain Wellness™* is specially formulated to help people address mild cognitive impairment and high homocysteine blood levels. One caplet a day can help preserve mental sharpness and improve your overall quality of life.

        4 Reasons to Choose Cerefolin Brain Wellness™

        • Neurologist Recommended*

          This dual-action targeted nutrition product helps lower homocysteine levels.1-2Your body needs this amino acid, but high levels of homocysteine increase risk of MCI.

        • Slows Brain Shrinkage

          In a clinical study, patients with high homocysteine levels taking Cerefolin Brain Wellness™* showed an 11.2 times slower rate of brain atrophy compared to those not taking it.1

        • Long-Term Results

          Cerefolin Brain Wellness™* is backed by an MRI study and up to 7 years of clinical data from the same patients, showing long-term use may help slow cognitive decline and maintain essential brain function.1, 3

        • Clinically Tested Ingredients

          High-quality ingredients have been clinically tested to ensure safety and effectiveness of our product.

            Brain Boosting Antioxidant Power

            Active Folate

            L-Methylfolate is the active form of folate that supports memory and focus-related neurotransmitter production, while improving brain metabolism.

            Vitamin B12

            Methylcobalamin (vitamin B12) boosts energy production to support overall brain function.

            NAC

            N-Acetyl-l-cysteine (NAC) contributes to brain health by reducing oxidative stress.

            Supporting Your Brain Today For a Better Tomorrow

            Memory problems, difficulty focusing, and stumbling over words can be startling. No one wants to lose brain function, especially when you still feel able and active otherwise. Starting Cerefolin Brain Wellness™ early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.1-4*

            What people are saying

            • "I'm very appreciative of your wonderful service and also your great product."“lrecommend it to everybody."

              -Tressie

            • "Those things really work." “I'm not going to the refrigerator looking for ketchup and forgetting what l went to it for."
              -George

            • "I believe that CerefolinNAC* helped me tremendously with my day to day thinking.

              -Monica

            • "l am feeling improvements from taking CerefolinNAc®*." "We have many good years ahead of us to enjoy the activelives we lead."
              -Tessa

            • "This has been a night and day difference.l feel like myself again."
              - Roland

            • "l am doing much better."

              - Laura

            • "l used to forget things a lot, but still a little, but not like before.Before it was terrible.l would even cry.l would get frustrated because my forgetfulness was so bad."
              -Cecelia

              Blog posts

              1 2

              Find Answers Here

              What is targeted nutrition?

              Targeted nutrition products are medical foods specially formulated with active (bioavailable) nutrients you cannot get through diet alone to meet the distinct nutritional requirements to address a certain condition—in this case, Mild Cognitive Impairment (MCI). A medical food should be taken under medical supervision.

              What is Cerefolin Brain Wellness™ and what are the ingredients?

              Cerefolin Brain Wellness™ is a targeted nutrition product for use under medical supervision for the clinical dietary management of Mild Cognitive Impairment in patients with hyperhomocysteinemia (high homocysteine blood levels). It is specially formulated to meet the distinctive nutritional requirements for this condition.

              Dietary ingredients include: 6 mg of L-Methylfolate calcium (active folate), 2 mg Methylcobalamin (Vitamin B12), and 600 mg N-Acetyl-l-cysteine (NAC). All ingredients: N-Acetyl-l-cysteine (NAC), Microcrystalline Cellulose and Silicon Dioxide, Hypromellose, L-Methylfolate Calcium, Magnesium Stearate (NF, Vegetable Source), Methylcobalamin.

              What is active folate and why is It important for brain health?

              L-Methylfolate is an active folate, which means your body can absorb it and make use of it without having to take additional steps to break it down and activate it. L-Methylfolate may affect certain chemicals in the brain important for memory, cognitive function and brain health. It helps address underlying imbalances to help you retain your ability to learn, understand, and remember.

              How does Cerefolin Brain Wellness™ work?

              Cerefolin Brain Wellness™ works by providing essential nutrients for brain health, that help to manage memory loss symptoms. The three nutrients include:

              • L-Methylfolate, the active form of folate that supports memory and focus-related neurotransmitter production, while improving brain metabolism.5
              • N-Acetyl-l-cysteine (NAC) contributes to brain health by reducing oxidative stress. 10
              • Methylcobalamin boosts energy production to support overall brain function.9

              These ingredients efficiently decrease homocysteine levels, which over time can help limit blood vessel damage and brain shrinkage linked to cognitive decline.

              What are the benefits of a “dual-action” formula?

              The ingredients in Cerefolin Brain Wellness™ are formulated for dual action in the brain: 

              1. Improves brain health, memory, focus and concentration
              2. Slows cognitive decline and brain atrophy

              How is Cerefolin Brain Wellness™ different from other product options?

              Cerefolin Brain Wellness™ began as a targeted nutrition product prescribed by neurologists and is recommended by neurologists to address the early signs of mild cognitive decline, protecting memory and cognitive function*. The ingredients in Cerefolin Brain Wellness™ are different from the ingredients found in most folic acid products.  Its formula provides the body with already-active folate (which means it can be absorbed and immediately used by the body because it doesn’t need to be broken down or activated), N-Acetyl-l-cysteine, and B12 that the body needs to address symptoms of Mild Cognitive Impairment (MCI). Most folic acid products need to be broken down in the body before the folate can be used, and many people may not be able to fully complete this activation.

              Does Cerefolin Brain Wellness™ preserve memory and slow cognitive decline?

              The dietary ingredients in Cerefolin Brain Wellness™ have been shown in multiple studies to support memory, brain health and cognitive function*. In a real-world study with patients with high homocysteine levels and memory loss, Cerefolin Brain Wellness™ delayed brain atrophy up to 11.2 times better than patients not taking Cerefolin Brain Wellness™ and significantly improved quality of life scores. Other clinical studies showed Cerefolin Brain Wellness™ supports memory retention and executive function (thinking, decision making), helping patients maintain focus and perform memory-related tasks.1-4.

              How do I know if Cerefolin Brain Wellness™ can help me?

              If you are noticing changes in memory or thinking and are concerned about mild cognitive decline, talk to your healthcare provider and try Cerefolin Brain Wellness™. Cerefolin Brain Wellness™ is targeted nutrition that can address certain nutrient imbalances in the brain and help you retain your ability to learn, remember, and understand, and protect this cognitive function longer than going without it. Everyone is different, so results can vary and it will take some time to work.

              How long does it take to notice results?

              Some people notice results in as little as 45 days, but timing and results vary. We typically recommend people take it for at least 12 weeks to start noticing results.

              Can I take Cerefolin Brain Wellness™ with other medications or supplements?

              It is typically safe to take Cerefolin Brain Wellness™ with other cognitive therapies and other medications, but it is always smart to talk to your healthcare provider to be sure.

              Does Cerefolin Brain Wellness™ have any contraindications?

              Cerefolin Brain Wellness™ is contraindicated in patients with known hypersensitivity to any of the components contained in this product.